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湘雅医院2015影像医学与核医学(放射)复试笔试题(回忆)
专业课(2h)
一、多项选择题(45*1分)
二、名词解释(4*2.5分)
1、骨膜三角2、支气管气像 3、心胸比值 4、跳跃征
三、简答(2*5分)
1、肝血管瘤的CT平扫及增强表现
2、脊柱结核的主要X线表现
四、问答题(2*10分)
1、外周型肺癌与肺结核球的鉴别
2、良恶性骨肿瘤的鉴别
五、论述题(1*15分)
患者肝硬化失代偿期，食管胃底静脉曲张，呕血史。
首选检查?食管胃底静脉曲张的主要X线表现?疾病机理?鉴别诊断?
复试英语(全院一样)(1h)
(Oncogeneadvance online publication, 16 March 2015; doi:10.1038/onc.2015.44.)
Cell growth density modulates cancer cellvascular invasion via Hippo pathway activity and CXCR2 signaling.
Abstract
Metastasis of cancer cells involvesmultiple steps, including their dissociation from the primary tumor andinvasion through the endothelial cell barrier to enter the circulation andfinding their way to distant organ sites where they extravasate and establishmetastatic lesions. Deficient contact inhibition is a hallmark of invasivecancer cells, yet surprisingly the vascular invasiveness of commonly studiedcancer cell lines is regulated by the density at which cells are propagated inculture. Cells grown at high density were less effective at invading anendothelial monolayer than cells grown at low density. This phenotypicdifference was also observed in a zebrafish model of vascular invasion ofcancer cells after injection into the yolk sac and extravasation of cancercells into tissues from the vasculature. The vascular invasive phenotypes werereversible. A kinome-wide RNA interference screen was used to identify driversof vascular invasion by panning small hairpin RNA (shRNA) library-transducednoninvasive cancer cell populations on endothelial monolayers. The selection ofinvasive subpopulations showed enrichment of shRNAs targeting the large tumorsuppressor 1 (LATS1) kinase that inhibits the activity of the transcriptionalcoactivator yes-associated protein (YAP) in the Hippo pathway. Depletion ofLATS1 from noninvasive cancer cells restored the invasive phenotype.Complementary to this, inhibition or depletion of YAP inhibited invasion invitro and in vivo. The vascular invasive phenotype was associated with aYAP-dependent upregulation of the cytokines IL6, IL8 and C-X-C motif ligand 1,2 and 3. Antibody blockade of cytokine receptors inhibited invasion andconfirmed that they are rate-limiting drivers that promote cancer cell vascularinvasiveness and could provide therapeutic targets
临床技能考核(8min)
腹腔穿刺、胸腔穿刺、骨髓穿刺、腰椎穿刺、导尿术、消毒铺巾、穿脱隔离衣、心肺复苏、胃管置入术、换药拆线等
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